New publication
Activity exploration of oridonin and its prodrug HAO472 on SARS-CoV-2 Nsp9 by native MS
The group has found that the prodrug HAO472 directly binds to Nsp9, establishing replacement of the labile ester with a bioisostere as a candidate drug strategy. We further tested oridonin and HAO472 against two Nsp9 variants from human coronavirus 229E (HCoV-229E) and ferret systemic coronavirus F56 (FSCoV-F56). Both compounds showed significant binding selectivity to COVID-19 and HCoV-229E Nsp9 over FSCoV-F56 Nsp9, confirming the covalent bond with Cys73.
This work entitled "Binding Studies of the Prodrug HAO472 to SARS-Cov-2 Nsp9 and Variants" has been published by ACS Omega. DOI: https://doi.org/10.1021/acsomega.1c07186
