Decoding the Language of Nature Using Native Mass Spectrometry
Target identification
The research in Professor Ronald J Quinn and Dr Miaomiao Liu’s Laboratory focuses on the development of a native mass spectrometry-based approach for target identification.
PROTACs
The research group has successfully detected ternary complex formed between a target protein, a PROteolysis Targeting Chimera (PROTAC) and an E3-ubqiutin ligase by using native mass spectrometry.
Natural products
Professor Ronald J Quinn and Dr Miaomiao Liu's group works on bioactive natural product purification and identification from various sources, e.g. plants, marine organisms, micro-organisms.
PhenoTarget
The group has developed an approach that combines phenotypic-based drug discovery and target-based drug discovery—PhenoTarget—to identify active compounds from natural resources.